Title
Examination of intraductal papillary mucinous neoplasms of pancreas and their association with extrapancreatic malignancies
Creator
Panić, Nikola M., 1984-
Copyright date
2017
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
English
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 20.03.2017.
Other responsibilities
mentor
Bulajić, Milutin, 1972-
mentor
Boccia, Stefania
član komisije
Pekmezović, Tatjana, 1964-
član komisije
Simić, Tatjana, 1964-
član komisije
Novaković, Ivana, 1961-
član komisije
Krstić, Miodrag, 1961-
član komisije
Nagorni, Aleksandar
Academic Expertise
Medicinske nauke
University
Univerzitet u Beogradu
Faculty
Medicinski fakultet
Alternative title
Ispitivanje intraduktalnih papilarnih mucinoznih neoplazmi pankreasa i njihove povezanosti sa ekstrapankreasnim malignitetima
Publisher
[N. M. Panić]
Format
63 lista
description
Epidemiology - Gastroenterology / epidemiologija - gastroenterologija
Abstract (en)
The primary objective of the thesis is to assess the prevalence and the
incidence of extrapancreatic malignancies (EPMs) in a cohort of Italian patients
diagnosed with intraductal papillary mucinous neoplasms (IMPNs) of pancreas, and to
identify the risk factors for their occurrence. The secondary objective is to assess an
association between pancreatic IPMN and selected single nucleotide polymorphisms
(SNPs) within 8q24 region of human genome. The tertiary objective of the thesis is to
assess whether patients with pancreatic IPMNs have an increased propensity to develop
colorectal adenomas.
Methods: In order to meet the objectives three separate studies were conducted: the
hospital-based multicentric study, the genetic association study and the colonoscopic
case-control study.
The hospital-based multicentric study was conducted in Italy from January 2010 to
January 2011 in eight participating centers. Three hundred ninety IPMN cases were
included in the study and screened for EPMs. EPMs were grouped according to time of
their diagnosis as previous, synchronous (both prevalent) and metachronous (incident).
The distribution of demographics, medical history and lifestyle habits was assessed
among cases. The observed/expected (O/E) ratio of prevalent EPMs was calculated.
The genetic association study was performed on 117 IPMN cases and 231 age and
gender matched controls. Cases were enrolled at the Digestive Endoscopy Unit,
Policlinico Agostino Gemelli, Rome, Italy with either a prevalent or incident IPMN
diagnosis, diagnosed from January 2010 to June 2011. Status of selected SNPs
(rs6983267, rs6993464, rs7014346, rs10505477) was determined using a StepOne Realtime
PCR system (Applied Biosystems) and TaqMan SNP Genotyping Assay ™ 40X.
Unconditional multiple logistic regression models were used to estimate odds ratios
(ORs) and 95% confidence intervals (CIs) for the association of selected SNPs and
IPMNs...
Authors Key words
pancreas, intraductal papillary mucinous neoplasm, extrapancreatic
malignancies, single nucleotide polymorphism, 8q24 region, colorectal cancer,
colonoscopy, adenomatous polyps
Authors Key words
pankreas, intraduktalne papilarne mucinozne neoplazme,
ekstrapankreasni maligniteti, 8q24 region humanog genoma, kolorektalni karcinom,
kolonoskopija, adenomatozni polipi
Classification
616.37-006.6(043.3)
Type
Tekst
Abstract (en)
The primary objective of the thesis is to assess the prevalence and the
incidence of extrapancreatic malignancies (EPMs) in a cohort of Italian patients
diagnosed with intraductal papillary mucinous neoplasms (IMPNs) of pancreas, and to
identify the risk factors for their occurrence. The secondary objective is to assess an
association between pancreatic IPMN and selected single nucleotide polymorphisms
(SNPs) within 8q24 region of human genome. The tertiary objective of the thesis is to
assess whether patients with pancreatic IPMNs have an increased propensity to develop
colorectal adenomas.
Methods: In order to meet the objectives three separate studies were conducted: the
hospital-based multicentric study, the genetic association study and the colonoscopic
case-control study.
The hospital-based multicentric study was conducted in Italy from January 2010 to
January 2011 in eight participating centers. Three hundred ninety IPMN cases were
included in the study and screened for EPMs. EPMs were grouped according to time of
their diagnosis as previous, synchronous (both prevalent) and metachronous (incident).
The distribution of demographics, medical history and lifestyle habits was assessed
among cases. The observed/expected (O/E) ratio of prevalent EPMs was calculated.
The genetic association study was performed on 117 IPMN cases and 231 age and
gender matched controls. Cases were enrolled at the Digestive Endoscopy Unit,
Policlinico Agostino Gemelli, Rome, Italy with either a prevalent or incident IPMN
diagnosis, diagnosed from January 2010 to June 2011. Status of selected SNPs
(rs6983267, rs6993464, rs7014346, rs10505477) was determined using a StepOne Realtime
PCR system (Applied Biosystems) and TaqMan SNP Genotyping Assay ™ 40X.
Unconditional multiple logistic regression models were used to estimate odds ratios
(ORs) and 95% confidence intervals (CIs) for the association of selected SNPs and
IPMNs...
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